In vitro characterization of self-emulsifying drug delivery system-based lipsticks loaded with ketoconazole

Abstract Background Self-emulsifying system-based lipstick may prove to have the potential of enhancing moisturizing characteristics and delivering hydrophobic drug antifungal drugs for management lip fungal infection, especially candidiasis. In this study, self-emulsifying delivery system (SEDDs) ketoconazole was obtained using IPM (Oil), Tween 80 (surfactant), PEG 400 (co-surfactant). The medicinal developed from SEDDs, concentration waxes (beeswax carnauba wax) cow ghee (penetration enhancer) optimized a Box–Behnken design. formulations were assessed based on physicochemical features, such as pH, spreadability, softening point, breaking content uniformity, in vitro permeation. Furthermore, optimal formulation tested stability activity. Results showed exceptional results analysis ~ 87% release 12 h. displayed adequate 4 weeks at various temperature conditions room temperature, 40 °C, 45 °C. zone inhibition produced by significantly higher compared reference standard (ketoconazole ethanol) which shows high Conclusion It concluded outcomes that SEDDs-based lot promise topical treatment option Candidiasis. Graphical abstract